RPA2 anticorps (pSer4, pSer8)

N° du produit ABIN7455212

Cet anticorps anti-RPA2 est un anticorps Lapin Polyclonal détectant RPA2 dans WB, IP, IF/ICC et IHC (fp). Adapté pour Humain et Souris.

Aperçu rapide pour RPA2 anticorps (pSer4, pSer8) (ABIN7455212)

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPA2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-RPA2 anticorps

Épitope: pSer4, pSer8

Fonction: Rabbit anti-Phospho RPA32 (S4/S8) Antibody, Affinity Purified

Homologie: Orangutan

Purification: Affinity Purified

Immunogène: surrounding serine 4/8

Isotype: IgG

Information d'application

Indications d'application:

ICC-IF: 1:500 - 1:5,000

IHC: 1:500 to 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur RPA2

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Autre désignation: RPA32

Sujet: Background: Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32 kDa (RPA2), and 14 kDa (RPA3). RPA2, the 32 kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK.

ID gène: 6118

NCBI Accession: NP_002937

UniProt: P15927

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA